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pentobarbital will minimize the extent or result of imatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.Monitor Intently (one)pentobarbital will lessen the level or result of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Loss of, or reduced response to